Fast HLA typing for smaller sample volumes and confirmatory tests? Look forward to extremely simple handling with HISTO TYPE SSP Kits. It is considered a robust and well established solution for low-resolution typing based on sequence-specific primers.
- Reliable: Robust against fluctuations in DNA concentration.
- Convenient: user-friendly HISTO MATCH software for evaluation and documentation for all loci
- Easy to implement: only basic PCR laboratory equipment needed (thermocyler and gel electrophoresis)
Thanks to the CE -certified and validated Taq polymerase, HISTO TYPE SSP sets quality standards.
The KIR TYPE SSP Kit allows genotyping of 14 Killer cell Immunoglobulin-like Receptor (KIR) genes plus 2 pseudogenes. It gives additional information on possible disparities between KIR and the respective HLA ligands in the context of transplantation.
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HISTO TYPE SSP - in disease associations and pharmacogenomics
Benefit from our simple SSP solutions for specific clinical applications related to HLA alleles.
Coeliac disease is strongly associated with the DQA1*05:01- DQB1*02:01 and DQA1*03-DQB1*03:02 haplotype. Additionally, DRB1*03, DRB1*07 and DRB1*11 alleles can be used as genetic markers.
Seronegative arthritic diseases like Morbus Bechterew, Morbus Reiter and post infectious reactive arthritis are strongly associated with HLA B*27. Determination of the presence of HLA B*27 is a valuable tool in the diagnosis of these diseases.
98 % of the Caucasian narcolepsy patients carry the DRB1*15:01- DQA1*01:02-DQB1*06:02 haplotype.
Some patients develop a hypersensitivity reaction against the antire- troviral drug abacavir which is used e.g. for HIV therapy. This hypersensitivity is associated with the allele HLA B*57:01
KIR typing is used as complimentary diagnostic before bone marrow transplantations and for immunogenetic studies. The KIR TYPE kit enables genotyping of 14 KIR genes and 2 pseudogenes.
- cost effective because of kit format with Happy Taq Polymerase included
- reliable results - Happy Taq Polymerase is CE certified and validated
- free user-friendly HISTO MATCH software for evaluation and documentation
- easy to implement because only basic PCR lab equipment is needed
HISTO TYPE SSP is the rapid HLA typing based on sequence-specific primers. The kits are optimal for smaller quantities and confirmation tests at low resolution. Easy evaluation is provided by the user-friendly HISTO MATCH software.
Cost-effective controls for optimal conditions
CYCLER CHECK - Temperature on trial
Regular checks and calibrations of your thermal cyclers are required by EFI and ASHI guidelines. The CYCLER CHECK, which is adapted to our SSP kits, tests the complete 96-well thermoblock for critical deviations in denaturation and annealing temperature. Rely on the easy and cost-effective verification of the temperature accuracy and uniformity of your thermal cycler.
Wipe test for quality assurance
Regular wipe tests are mandatory according to the EFI and ASHI guidelines. The use of the wipe test avoids false positive reactions and thus ensures the quality of your results!
Our wipe test offers you a reliable and fast method to check for contamination with amplicons of the HLA class I and class II genes as well as with genomic DNA in the laboratory.
