Coeliac disease is an autoimmune reaction triggered by gluten which is an ingredient of different cereals. If not diagnosed early this leads to chronic inflammation and destruction of the small intestine. Coeliac disease is strongly associated with the DQA1*05- DQB1*02 and DQA1*03-DQB1*03:02 haplotype. Additionally, DR3, DR7 and DR11 alleles can be used as genetic markers. Carriers of HLA predisposition alleles probably have an up to 40 times higher risk of developing celiac disease. The confirmed diagnostic results of the HLA-DQ haplotypes make an important contribution to the therapy of a patient.
For coeliac disease diagnostics we offer the following kits: