Human genetics – our solutions

Diagnostics with long-term effect

Human genetic testing has become an integral part of almost all medical disciplines. Thanks to the great advances in genetic research, more than 1,000 diseases or disorders can now be linked to genetic dispositions.

On the basis of clinical, histological or biochemical findings alone, it is not always possible to make a pinpoint diagnosis. Human genetics enables chromosome analysis as well as the analysis of individual genes (molecular genetics). Both techniques complement each other.

Screening, diagnosis, prevention

In order to provide patients with more information on, for example, "family-typical" disease patterns, we have developed a series of highly efficient test kits. With their help, you can check whether the symptoms may have a genetic cause and whether they harbour hereditary genetic risks.

The confirmation or exclusion of specific genetic traits makes an important contribution to the selection of further examination methods as well as possible forms of therapy for the patients. The choice of tests in medical laboratories follows the increased demand.

Fetal Rhesus typing

Approximately 17% of pregnant women in Germany are Rhesus D-negative. If the fetus is Rhesus D-positive the pregnant woman can develop antibodies against the fetus and there may be complications. Therefore, currently all Rhesus D-negative pregnant women get immunoglobulins as Rhesus prophylaxis.

Now, through the use of modern non-invasive molecular fetal diagnostics via real-time PCR typing, pregnant women can have their blood tested for the Rhesus D status of the unborn child. Since July 2021, this molecular genetic prenatal determination has also been included as a health insurance benefit in Germany.

With the new FastQ® RHD fetal kit, dedicated anti-D prophylaxis is possible. The kit reliably detects the Rhesus D status of the fetus: 3 exons of the RHD gene are examined by real-time PCR analysis. By detecting the three exons 5, 7 and 10, the probability of a false negative result is extremely minimized.

We offer the following kits for fetal Rhesus typing:

  • Product
  • Bundle
  • REF
  • Certification
  • Compatibility
  • FastQ® RHD fetal
    Real-Time PCR Kit
  • 3 x 24 tests
  • 728210
  • Abacavir / Morbus Behcet

    Treatment with antiretroviral drugs containing the active substance Abacavir (mainly in HIV therapy) is only allowed when the existence of HLA-B*57:01 is excluded by molecular genetic methods, since otherwise it is possible that a hypersensitivity reaction against Abacavir may occur.

    Behcet’s disease is a chronic vasculitis characterized by recurrent oral ulcers, genital ulcers, ocular and skin involvement, and other multisystemic symptoms. Despite a worldwide distribution Behcet’s disease clusters in an area from eastern Asia to the Mediterranean basin. HLA B*51 is a strong risk factor for the disease and can be used as a diagnostic tool.

    We offer you a safe and reliable method for an unambiguous determination of the associated alleles.

  • Product
  • Bundle
  • REF
  • Certification
  • Compatibility
  • HISTO TYPE B*57:01 / B*51
    Classic SSP incl. 1x Happy Taq Polymerase, 7 Mixe + Contamination control
  • 20 tests
  • 70715
  • CE - Sign
  • Morbus Bechterew et al.

    There is a strong association between HLA-B27 and a group of seronegative arthritic diseases like Morbus Bechterew or Morbus Reiter. Determination of HLA-B27 is an important tool in the diagnosis of these diseases. All common and well documented (CWD) alleles, as well as most of the rare alleles are detected by our kits. Moreover, the non-associated alleles B*27:06 and B*27:09 can be differentiated with our real-time PCR kit FastQ® B*27.

    Especially in the case of unclear suspicion of Bechterew's disease, a reliable HLA-B*27 diagnosis makes a decisive contribution to the therapy of a patient.

    We offer different technologies for the detection of HLA-B27:

  • Product
  • Bundle
  • REF
  • Certification
  • Compatibility
  • FastQ® B*27
    Real time PCR Kit
  • 96 tests
  • 728208
  • CE - Sign
  • Cycler Compatibility Test
    Cycler Compatibility Test
  • FastQ® B*27 direct
    Real time PCR Kit directly from blood
  • 96 tests
  • 728201
  • CE - Sign
  • Cycler Compatibility Test
    Cycler Compatibility Test
  • HISTO TRAY B27 (10)
    Serological test (incl. 10 × 1 ml rabbit complement) for typing one specimen per tray
  • 10 panels
  • 7006
  • CE - Sign
  • HISTO TRAY B27 (10) forte
    Serological test (incl. 10 × 1 ml rabbit complement) for typing one specimen per tray
  • 10 panels
  • 7004
  • CE - Sign
  • HISTO TYPE B27 low
    Classic SSP incl. 1x Happy Taq Polymerase, 1 PCR Mix
  • 48 tests
  • 7070
  • CE - Sign
  • HISTO TYPE B27 low
    Classic SSP incl. 1x Happy Taq Polymerase, 1 PCR Mix
  • 96 tests
  • 7071
  • CE - Sign
  • Coeliac disease

    Coeliac disease is an autoimmune reaction triggered by gluten which is an ingredient of different cereals. If not diagnosed early this leads to chronic inflammation and destruction of the small intestine.

    Coeliac disease is strongly associated with the DQA1*05- DQB1*02 and DQA1*03-DQB1*03:02 haplotype. Additionally, DR3, DR7 and DR11 alleles can be used as genetic markers. Carriers of HLA predisposition alleles probably have an up to 40 times higher risk of developing celiac disease. The confirmed diagnostic results of the HLA-DQ haplotypes make an important contribution to the therapy of a patient.

    For coeliac disease diagnostics we offer the following kits:

  • Product
  • Bundle
  • REF
  • Certification
  • Compatibility
  • FastQ® CD
    Real-time PCR test
  • 48 tests
  • 728202
  • CE - Sign
  • Cycler Compatibility Test
    Cycler Compatibility Test
  • FastQ® CD direct
    Real-time PCR test
    +++ Coming soon +++
  • 48 tests
  • 728203
  • HISTO SPOT® Coeliac Disease
  • 48 tests
  • 726071
  • CE - Sign
  • HISTO TYPE Coeliac Disease
    incl. 1x Happy Taq Polymerase, 23 PCR Mixe + Contamination control
  • 20 tests
  • 70941
  • CE - Sign
  • Narkolepsy

    Narcolepsy belongs to a group of sleeping disorders (Dyssomnias) with symptoms like daytime somnolence, sleep paralysis and hallucinations. 98 % of the Caucasian patients with narcolepsy have the DRB1*15:01 – DQA1*01:02 – DQB1*06:02 haplotype. Therefore, HLA typing is helpful to confirm or exclude a diagnosis.

    For easy and safe typing of the above mentioned alleles, we offer a classic SSP kit.

  • Product
  • Bundle
  • REF
  • Certification
  • Compatibility
  • HISTO TYPE Narcolepsy
    Classic SSP incl. 1x Happy Taq Polymerase, 8 PCR Mixe + Contamination control
  • 20 tests
  • 70716
  • CE - Sign
  • Hereditary Hemochromatosis

    Hemochromatosis is one of the most common congenital diseases in Northern Europe. Due to an increased absorption of iron in the small intestine and accumulation, especially in the liver, spleen and pancreas, but also in the heart, joints and thyroid gland, these organs are injured.

    Hemochromatosis is mostly inherited is caused by the mutations H63D and C282Y on the HFE gene. If diagnosed early, the disease can be successfully treated, otherwise the organs are irreversibly injured.

    In order to enable an uncomplicated and fast diagnosis, we will soon offer the following kits:

  • Product
  • Bundle
  • REF
  • Certification
  • Compatibility
  • FastQ® HFE
    +++ Coming soon +++
  • 48 tests
  • 728206
  • FastQ® HFE direct
    +++ Coming soon +++
  • 48 tests
  • 728207
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