Human Genetics
Coeliac disease
Coeliac disease is an autoimmune reaction triggered by gluten which is an ingredient of different cereals. If not diagnosed early this leads to chronic inflammation and destruction of the small intestine. Coeliac disease is strongly associated with the DQA1*05- DQB1*02 and DQA1*03-DQB1*03:02 haplotype. Additionally, DR3, DR7 and DR11 alleles can be used as genetic markers. Carriers of HLA predisposition alleles probably have an up to 40 times higher risk of developing celiac disease. The confirmed diagnostic results of the HLA-DQ haplotypes make an important contribution to the therapy of a patient.
For coeliac disease diagnostics we offer the following kits:
Real-time PCT test
Real-time PCT test
+++ Coming soon +++
incl. 1x Happy Taq Polymerase, 23 PCR Mixe + Contamination control
Morbus Bechterew et al.
There is a strong association between HLA-B27 and a group of seronegative arthritic diseases like Morbus Bechterew or Morbus Reiter. Determination of HLA-B27 is an important tool in the diagnosis of these diseases. All common and well documented (CWD) alleles, as well as most of the rare alleles are detected by our kits. Moreover, the non-associated alleles B*27:06 and B*27:09 can be differentiated with our real-time PCR kit FastQ® B*27. Especially in the case of unclear suspicion of Bechterew's disease, a reliable HLA-B*27 diagnosis makes a decisive contribution to the therapy of a patient.
We offer different technologies for the detection of HLA-B27:
Real time PCR Kit
Real time PCR Kit directly from blood
Serological test (inkl. 10x1 ml Kaninchenkomplement) zur Typisierung eines Probanden/Platte
Serological test (inkl. 10x1 ml Kaninchenkomplement) zur Typisierung eines Probanden/Platte
Classic SSP incl. 1x Happy Taq Polymerase, 1 PCR Mix
Classic SSP incl. 1x Happy Taq Polymerase, 1 PCR Mix
Abacavir / Morbus Behcet
Treatment with antiretroviral drugs containing the active substance Abacavir (mainly in HIV therapy) is only allowed when the existence of HLA-B*57:01 is excluded by molecular genetic methods, since otherwise it is possible that a hypersensitivity reaction against Abacavir may occur.
Behcet’s disease is a chronic vasculitis characterized by recurrent oral ulcers, genital ulcers, ocular and skin involvement, and other multisystemic symptoms. Despite a worldwide distribution Behcet’s disease clusters in an area from eastern Asia to the Mediterranean basin. HLA B*51 is a strong risk factor for the disease and can be used as a diagnostic tool.
We offer the following kit for detection of the associated alleles:
Classic SSP incl. 1x Happy Taq Polymerase, 7 Mixe + Contamination control
Narkolepsy
Narcolepsy belongs to a group of sleeping disorders (Dyssomnias) with symptoms like daytime somnolence, sleep paralysis and hallucinations. 98 % of the caucasian patients with narcolepsy have the DRB1*15:01 – DQA1*01:02 – DQB1*06:02 haplotype. Therefore, HLA typing is helpful to confirm or exclude a diagnosis.
For easy and safe typing of the above mentioned alleles, we offer the following product.
Classic SSP incl. 1x Happy Taq Polymerase, 8 PCR Mixe + Contamination control
Hereditary Hemochromatosis
Hemochromatosis is one of the most common congenital diseases in Northern Europe. Due to an increased absorption of iron in the small intestine and accumulation, especially in the liver, spleen and pancreas, but also in the heart, joints and thyroid gland, these organs are injured.
Hemochromatosis is mostly inherited is caused by the mutations H63D and C282Y on the HFE gene. If diagnosed early, the disease can be successfully treated, otherwise the organs are irreversibly injured.
In order to enable an uncomplicated and fast diagnosis, we will soon offer the following kits:
+++ Coming soon +++
+++ Coming soon +++
| 728206 | FastQ® HFE +++coming soon+++ |
48 tests |
| 728207 | FastQ® HFE direct +++coming soon+++ |
48 tests |
